Igbang Jerome Okputu
Department of Biochemistry, University of Calabr, Calabar 540281, NigeriaPublications
-
Research
Comparative Study on the Biochemical Effects of Gin and Lager Beer, and their concomitant Administration with Tramadol in Wistar Rats.
Author(s): Victor Samson Ekam, Echu Francis Obun, Igbang Jerome Okputu* and Kevin Douglas Abang
Background: Tramadol is a synthetic opiate drug primarily used in treating mild to severe pain. It abuse among youth in concomitant intakes with alcoholic beverages like gin and lager beer is associated with changes in biochemical parameters such as, lipid profile, haematological parameters, liver enzymes, urea and creatinine levels, antioxidant, electrolytes concentration, changes in growth rate and body weight as well as liver and kidney damages. Methods: A total of 24 Wistar rats weighing between 83.24 g to 118.92 g were divided into six groups and were given tramadol, gin, lager beer and a concomitant dose of tramadol with lager beer and gin respectively, for 21 days. Results: The mean value significant decreased (p<0.05) in growth and body weight in concomitant intake of tramadol and lager beer .. Read More»
DOI: 10.4303/JDAR/236450