Vikas Kaushik

Department of Bioinformatics, University of Sadat City, Egypt


  • Research Article   
    An In-silico Study for Available Microarray Datasets Analysis for Tropheryma whipplei to Evaluate Impact of Drug and Thermic Stress
    Author(s): Amit Joshi and Vikas Kaushik*

    Tropheryma whipplei is a Gram-positive rod-shaped bacteria, a member of the Actinobacteria division that causes Whipple’s disease. This disease is very harmful as it can cause multiple organ failure including lipodystrophy of intestine and central nervous system functionality. Therefore this study was found crucial for identification of genes that are affected within T. whipplei due to temperature and commonly used drug Doxycycline. This will assist in future drug repurposing against the bacterium. The Gene expression profiling analysis was performed using GEO2R that compares two or more groups of samples in order to identify genes that are differentially expressed across experimental conditions. Force normalization which uses quantile normalization was applied for the array normalization to the expression data making all sele.. Read More»
    DOI: 10.4303/JDAR/236206

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