Shiva Kumar Gubbiyappa

Department of Pharmacy, School of Pharmacy, GITAM Deemed to be University, Rudraram, Patancheru, Hyderabad, Telangana, India

Publications

• Research   
  Development and Evaluation of Stable Minitablets Containing Suvorexant Infused Self-Emulsifying Drug Delivery Systems
  Author(s): Boddu Lakshmi Satya* and Shiva Kumar Gubbiyappa
  
  The present study proposes to prepare minitablets where Suvorexant- loaded Self-Emulsifying Drug Delivery Systems (SEDDS) will be employed to overcome its poor solubility in water and achieve an increased oral bioavailability. The testing of different types of liquid excipients (lipid-based) including Transcutol HP, Tween 80, Acconon, and Labrasol ALF were tested in terms of their solubilisation properties. The optimised Self-Emulsifying Drug Delivery Systems (SEDDS) with composition of Transcutol HP (30 v/v), Tween 80 (45 v/v), Acconon (20v/v) and Labrasol ALF (5v/v) had a desirable emulsification time, average drop size of about 130 nm and good release of the drug in media approved by the USFDA. To provide a solid SEDDS, formulations were adsorbed to porous and non-porous carriers alike and then compressed down to minitablets. Characterisation included in vitro release studies, flow.. Read More»
  DOI: 10.4303/JDAR/236451

  Abstract HTML PDF