Nithya Panneerselvam
Department of Pharmacology, Faculty of Medicine, Sri Lalithambigai Medical College and Hospital, Dr. MGR Educational and Research Institute, Chennai, Tamilnadu, India, Ph.D Schol, IndiaPublications
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Research Article
Effects of Methoxyflavone and their Derivatives on Memory Deficits Induced by Scopolamine in Zebrafish Models of Alzheimer?s Disease
Author(s): Nithya Panneerselvam*, Parimala Kathirvelu* and Hemanthkumar Shanmugam*
Background: Dementia, predominantly caused by Alzheimer’s disease (60-70% of cases), represents a significant disease burden. As methoxyflavones from Kaempferia parviflora possess AChE-inhibition properties, synthetic methoxyflavones and their derivatives were chosen for their therapeutic potential in established zebrafish neurodegenerative models. Aim: To study the effect of methoxyflavone and its synthetic derivatives in scopolamine-induced memory deficit models of Zebrafish. Methodology: 12 groups of Adult Danio rerio (10 fish per tank) were used. A stock solution of all three test drugs (7-methoxyflavone, 7,4’ dimethoxyflavone, and 7,2’,4’ trimethoxyflavone – in doses of 5,10,20 mg), standard Rivastigmine 1.5 mg/kg, and scopolamine 200 μM were prepared & diluted to the desired volume of stock solution.. Read More»