Lourdes de Fatima Ibanez Valdes

Department of Neurology, Walter Sisulu University (WSU), South Africa

Publications

• Research Article   
  Novel Hypotheses on Neurophatic Pain in Isaacs Sydrome and Drug Therapy
  Author(s): Lourdes de Fatima Ibanez Valdes and Humberto Foyaca Sibat*
  
  Introduction: In 2001, we reported two patients with Isaacs' syndrome who responded remarkably well clinically and electromyographically to low oral doses of phenytoin. Isaacs Syndrome (IS) is characterized by recurrent spontaneous muscle activity of the peripheral nerve source that can be triggered by induced muscle contraction or voluntary muscular activity. Some authors have proposed an autoimmune aetiology based on clinical events suggesting a possible autoimmune aetiology, including the presence of oligoclonal bands in the cerebrospinal fluid and a good response to plasmapheresis. The primary aim of this study is to answer the following research questions: What is the pathophysiology of neuritic pain in patients presenting to IS? What is the best drug therapy choice? Methods: We searched the literature, following the guidelines outl.. Read More»
  

  Abstract PDF