Fu Changgeng
National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China academy of Chinese Medical Sciences, Beijing, 100195, ChinaPublications
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Review Article
Mitochondrial Dysfunction in Parkinson?s Disease: Mechanistic Insights and Emerging Therapeutic Strategies
Author(s): Anastasia V. Poznyak*, Alexander L. Golovyuk, Fu Changgeng, Li Hongzheng, Elizaveta Romanovna Korchagina and Alexander N. Orekhov
Mitochondrial dysfunction is a major contributor to multifactorial neurodegenerative disease, Parkinson’s Disease (PD). The molecular links between mitochondrial dysfunction and the causes of PD are summarised here in light of our current knowledge. Using data from genetic and subjective studies, we identify the mitochondrial pathways impacted by α-synuclein aggregation, oxidative stress, dysregulated calcium signalling, and reduced mitophagy. Particular focus is on the link between mitochondria, lysosomes, and the endoplasmic reticulum as well as how these interorganelle interactions contribute to neuronal vulnerability. Evidence gathered suggests a decline in oxidative phosphorylation, an increase in Reactive Oxygen Species (ROS) production, and the activation of programmed cell death pathways as mitochondrial dysfunction contributes to dopaminergic neuron death. Further.. Read More»
DOI: 10.4303/JDAR/236471