Alexander L. Golovyuk

Vascular Surgery Department, A. V. Vishnevsky National Medical Research Center of Surgery, 27 Bolshaya Serpukhovskaya Street, 117997 Moscow, Russia

Publications

• Review Article   
  Mitochondrial Dysfunction in Parkinson?s Disease: Mechanistic Insights and Emerging Therapeutic Strategies
  Author(s): Anastasia V. Poznyak*, Alexander L. Golovyuk, Fu Changgeng, Li Hongzheng, Elizaveta Romanovna Korchagina and Alexander N. Orekhov
  
  Mitochondrial dysfunction is a major contributor to multifactorial neurodegenerative disease, Parkinson’s Disease (PD). The molecular links between mitochondrial dysfunction and the causes of PD are summarised here in light of our current knowledge. Using data from genetic and subjective studies, we identify the mitochondrial pathways impacted by α-synuclein aggregation, oxidative stress, dysregulated calcium signalling, and reduced mitophagy. Particular focus is on the link between mitochondria, lysosomes, and the endoplasmic reticulum as well as how these interorganelle interactions contribute to neuronal vulnerability. Evidence gathered suggests a decline in oxidative phosphorylation, an increase in Reactive Oxygen Species (ROS) production, and the activation of programmed cell death pathways as mitochondrial dysfunction contributes to dopaminergic neuron death. Further.. Read More»
  DOI: 10.4303/JDAR/236471

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