Alexander N. Orekhov

Institute for Atherosclerosis Research, Osennyaya 4-1-207, 121609 Moscow, Russia

Publications

• Review Article   
  Mitochondrial DNA and Inflammation: Mechanisms of Release and Signaling Pathways
  Author(s): Anastasia V. Poznyak*, Elizaveta Romanovna Korchagina, Fei Liu, Yanke Shan and Alexander N. Orekhov
  
  Mitochondria (Mt) play a crucial role in various cellular processes, including energy production and metabolism. Damage-Associated Molecular Patterns (DAMPs) released by mitochondria, such as mitochondrial DNA (mtDNA), cardiolipin, succinate, and ATP, can trigger inflammation signaling pathways. This review article delves into the evolutionary origins of mitochondria from bacterial ancestors and their role as regulators of inflammation through DAMPs release. The intricate mechanisms of mtDNA leakage into the cytoplasm and extracellular space are explored, focusing on pathways involving the Mitochondrial Permeability Transition Pore (mPTP), Cell-Free mtDNA, and Extracellular Vesicles (EVs). Additionally, the involvement of key immune signaling pathways such as the cyclic GMP-AMP Synthase (cGAS)-Stimulator of Interferon Genes (STING), Toll-like receptor-9, and inflammasomes in recognizi.. Read More»
  

  Abstract PDF