Alexander N. Orekhov
Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 8 Baltiiskaya Street, Moscow 125315, RussiaPublications
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Review Article
Neuroinflammatory Pathways in Parkinson's Disease: Understanding Triggers and Treatment Approaches
Author(s): Anastasia V. Poznyak*, Aleksey Aleksandrovich Vatlin, Elizaveta Romanovna Korchagina, Olga Nikolaevna Maltseva, Aleksandra Sergeevna Utkina and Alexander N. Orekhov
Parkinson’s Disease (PD) is a prevalent neurodegenerative disorder characterized by a complex interplay of motor and non-motor symptoms, primarily resulting from the loss of dopaminergic neurons and the accumulation of pathological α-synuclein aggregates. Recent research underscores the significant role of neuroinflammation in the pathophysiology of PD, where chronic inflammatory processes contribute to neuronal degeneration. This review comprehensively examines the mechanisms underlying neuroinflammation in PD, highlighting the involvement of microglia, astrocytes, and peripheral immune responses. Various triggers, including α-synuclein aggregation, genetic predispositions, mitochondrial dysfunction, and gut microbiome dysbiosis, are discussed as potential instigators of neuroinflammatory cascades. Therapeutic strategies aimed at mitigating neuroinflammation, such a.. Read More»
DOI: 10.4303/JDAR/236457