New Hypotheseses on Pathogenesis of Depression in Parkinson?s Disease
Author(s): Humberto Foyaca Sibat
Abstract
Objectives: This study’s primary goal is to review the most recent data that has been published in the medical literature about the pathophysiology of depression in Parkinson’s disease.
Methods: To discover papers pertaining to new information on the pathophysiology of depression in Parkinson’s disease, a thorough search of the medical literature was conducted using the databases PubMed/ MEDLINE, Scopus, and Embase. We used PRISMA standards to search the medical literature between January 1, 2000, and January 31, 2026. The following terms were used to search Scopus, Embase, and PubMed Central: “Pathogenesis of depression,” “Pathogenesis of Parkinson’s disease,” “Microbiota,” “Gutbrain axis,” “Dysbiosis,” “Limbic system,” “Major depressive disorders,” “Dopaminergic dysfunction,” “Network-level disturbances,” and “Vagal Nerve (VN)”.
Results: 1563 articles were first found using a literature search. 652 publications remained after 911 duplicates were eliminated based on title and abstract review. Of these, 174 papers examined the pathophysiology of depression in Parkinson’s Disease (PD), as 478 did not fit the inclusion/ exclusion criteria. Twelve of these publications offered new insights into the pathophysiology of Parkinson’s disease. Nevertheless, a quality evaluation showed that none of the included papers offered novel theories.
Conclusions: Recent research has shown that depression in Parkinson’s disease is associated with dopaminergic dysfunction, network-level disruptions, dysbiosis, and neurodegeneration. processes. To the best of our knowledge, this review is the first to concentrate on new facets of the pathophysiology of depression in Parkinson’s disease. Additionally, it presents fresh theories regarding how the limbic system and other brain areas are impacted by the microbiome