Dercum?s Disease with Associated with Autonomic Manifestations, Novel Hypotheses on Pathophysiology of Neuritic Pain and Drug Therapy
Author(s): Lourdes de Fatima Ibanez Valdes, Sibi Joseph and Humberto Foyaca Sibat*
Abstract
Introduction: Dercum’s Disease (DD), also named Adiposis Dolorosa (AD). It is a chronic debilitating condition with various clinical presentation types confirmed through imaging. It is a sporadic syndrome characterized by multiple, painful, subcutaneous adipose tissues commonly localized in the abdomen and extremities. We reported a new case presenting different neurological manifestations.
Methods: We searched the literature, following the guidelines outlined in the PRISMA statement. From January 2023 to January 2025, the authors searched the scientific databases, Scopus, Embassy, Medline, and PubMed Central using the following searches: “Dercum’s disease” OR “adiposis dolorosa” OR “Pathophysiology of neuritic pain” OR “neuritic pain in adiposis dolorosa” OR “therapy of Dercum’s disease”, OR “mTOR in neuritic pain”.
Results: After screening the full-text articles for relevance, 22 articles were included for final review. However, no article was selected when we searched for DD/NP/documented pathogenesis/respond to drug therapy.
Conclusions: Based on the systematic review of the medical literature we also released novel hypotheses on the pathogenesis of neuritic pain in patients presenting DD. Obviously further investigations will support or reject our proposals.