Donna Adriani

Department of Phisiology, Universitas Trisakti, Indonesia


  • Review Article   
    Effects of Valproic Acid on Pregnancy in Epilepsy Patients
    Author(s): Triasti Khusfiani, Yudhisman Imran*, Irmiya Rachmiyani and Donna Adriani

    Valproic acid has long proven to be an effective drug for treating epilepsy and has been prescribed to pregnant women with epilepsy ever since. There are only few prospective studies regarding this drug during pregnancy, however several cohort studies have shown that women taking it during the first trimester have an increased risk of congenital disorders such as spina bifida, craniosynostosis, cleft palate, hypospadias, and more. Valproic acid also has a postnatal developmental disorder effect such as ADHD and ASD in children who were exposed to it before birth. Concerns about valproic acid and its teratogenic risks has led many women to discontinue their antiepileptic medication either before pregnancy or early in their pregnancy Even though it is highly recommended to minimize or even discontinue valproic acid use in pregnancy, but in some cases, the risks of discontinuing this dru.. Read More»
    DOI: 10.4303/JDAR/236245

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