Amit Joshi
Department of Biochemistry, Kalinga University, Atal Nagar-Nava Raipur, IndiaPublications
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Research Article
In silico Evaluation of Plant-Derived Phytochemicals as Potential Inhibitors of Acetyl-CoA Acyltransferase: A Comparative Study with the Drug Sandoz 58-035 in Lipid Metabolism Disorders
Author(s): Jharna Maiti, Amit Joshi* and Shivam Mishra
Lipid metabolic disorders are increasingly recognized as major contributors to cardiovascular diseases, obesity, and related metabolic complications worldwide. Although conventional drugs such as Sandoz-58-035 (CAS 78934-83-5) are widely used to control lipid levels, their long-term administration is often associated with adverse effects, highlighting the need for safer therapeutic alternatives. In the present study, an integrated in silico approach was employed to evaluate plant-derived phytochemicals as potential inhibitors of acetyl-CoA acyltransferase, a key enzyme involved in lipid metabolism. A total of 51 phytochemicals obtained from Bryophyllum pinnatum, Ocimum tenuiflorum, Camellia sinensis, and Tinospora cordifolia were screened using molecular docking analysis. Several compounds demonstrated strong binding affinity toward the target enzyme, with binding energies superior to.. Read More»