Amit Joshi

Department of Bioengineering and Biosciences, Lovely Professional University, India


  • Research Article   
    Quercetin Compound Analysis to Develop Treatment for Dementia Associated with Alzheimer?s disease in Humans: In-silico Study
    Author(s): Amit Joshi, Neha Vats, Himanshu Singh and Vikas Kaushik*

    Background: Alzheimer’s disease is a memory loss problem associated mostly with elderly people, the cause of this disease is generally accumulation of beta-amyloid plaques around neuronal parts especially synaptic knobs, and also impaired synthesis of Tau proteins (Taupathy), that are mostly involved in holding micro-tubular assembly required for trafficking neurotransmitter containing vesicles. New method: In this work, we perform computational analysis on the Quercetin molecule, an essential flavonoid that may stops the reaction participation tendency of beta-secretase biocatalyst, which could assist in the production of new treatments. Modern computational biology tools were deployed i.e., Swiss ADME for drug likeness, Auto-Dock Vina for molecular docking and Gromacs for molecular dynamics and simulation. Results: .. Read More»
    DOI: 10.4303/jdar/236174

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