Alexander N. Orekhov
Institute of Experimental Medicine, 12, Academician Pavlov Streets, 197022, Saint Petersburg, RussiaPublications
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Review Article
Systemic Sclerosis and Atherosclerosis: Potential Relations in the Cardiovascular Field
Author(s): Anastasia V. Poznyak*, Varvara A. Orekhova, Elizaveta Romanovna Korchagina, Olga Nikolaevna Maltseva, Vsevolod Vyacheslavovich Pavshintsev and Alexander N. Orekhov
Atherosclerosis, a chronic inflammatory condition of medium and large blood vessels, poses a significant risk for cardiovascular morbidity and mortality globally. This review examines the interplay between atherosclerosis and autoimmune diseases, particularly focusing on Systemic Sclerosis (SSc) due to its unique pathophysiological features. The involvement of inflammatory mediators-such as cytokines and immune cells-in accelerating atherosclerosis is highlighted, with particular emphasis on how traditional cardiovascular risk factors interact with disease-specific mechanisms. Patients with SSc face an increased cardiovascular risk, largely driven by immune dysregulation and endothelial dysfunction, which contribute to both microvascular and macrovascular complications. While research suggests a potential link between SSc and accelerated atherosclerosis, findings remain inconsistent, .. Read More»
DOI: 10.4303/JDAR/236456