In vitro cytotoxicity of four folklore medicinal herbs of Kodanthur tribal village at Chinnar, Udumalpet, Tamil Nadu, India
Author(s): Dhanabalan Rangasamy*, Lavanya Gunasekaran and Dhiviya Jeyarajan
Abstract
Four plant species Solanum trilobatum, Spathodea campanulata, Syzygium jambos and Tylophora indica leaf extracts extracted with aqueous, methanol, ethanol and chloroform were screened for cytotoxicity in MCF-7 cells. Among 16 extracts tested significant (p<0.01) cytotoxicity was exhibited by SJCLE (74.4%), and TICLE (64.04%) with an IC50 of 95.2 μg/mL and 119 μg/mL respectively. The extract SJELE was found to exhibit 70.6% cytotoxic to MCF 7 cells but IC50 was found to higher 123.4 μg/mL compared to SJCLE and TICLE. The other extracts SCCLE, TIMLE, SJMLE, TICLE and TIELE exhibited above 60% anti-proliferative activity with their IC50 concentrations ranging from 98 μg/ mL-132 μg/mL. Furthermore, other extracts such as STELE, STMLE, and SCELE unveiled 50%-58% cytotoxicity against MCF-7 cell line at the highest concentration 300 μg/mL.
