Exploring the Antibacterial Activities and Preliminary Sensing Studies of a Quinoline-Functionalized Thiosemicarbazone Derivative

Author(s): Waseem Shoukat, Mazhar Hussain, Natasha Mukhtiar, Shujaat Hussain, Muhammad Nadeem Shoukat, Muhammad Ghazanfar Bashir and Fazal Ur Rehman M.


This research paper describes the synthesis and characterization of a novel Thiosemicarbazone derivative 1 with a quinoline moiety functionalized to it. Spectroscopic techniques, including 1H and 13C NMR, UV-vis absorption, and fluorescence, were used to characterize the synthesized product. The compound was prepared as a solution in ACN and was subjected to various ions. The addition of different ions resulted in changes in color and fluorescence intensity of the compound. The antibacterial activity of the Thiosemicarbazone derivative was also evaluated against gram-positive and gram-negative bacteria using the Kirby-Bauer disc diffusion method. The compound was found to be moderately active against the tested bacterial strains, which could be attributed to the presence of the imine group (-C=N) in the compound. This study presents the first report of the antibacterial activity of benzylmethyl-4-methyl-3-thiosemicarbazone on bacteria. Further research on the compound’s activity against other pathogens, such as malaria and onchocerciasis, is recommended.

image 10.4303/JDAR/236224

Share this article