Area Postrema Syndrome and Novel Approaching of Drug Therapy
Author(s): Lourdes de Fatima Ibanez Valdes, Humberto Foyaca Sibat*
Abstract
Objectives: The main aim of this study is to discuss the last information released into the medical literature regarding to drug therapy in patients with Area Postrema Syndrome (APS) reported in the available medical literature.
Methods: A wide searching of the medical literature of the following database PubMed/MEDLINE, Scopus, and Embase databases performed to find articles related to novel information on APS and its diagnostic and therapeutic procedures. From 01st, January 1989 to 30th, January of 2026, we searched the medical literature, following the PRISMA guidelines. The authors searched the scientific databases, Scopus, Embassy, Medline, and PubMed Central using the following searches: “area postrema” OR “area postrema syndrome” OR “refractory nausea and vomiting” OR “intractable nausea, hiccups and vomiting”, OR “treatment/management of APS”.
Results: Searching literature retrieved 149 articles. 101 duplicated publications identified and after reviewing the titles and abstracts removed, forty?eight publications selected. After applying the inclusion/exclusion criteria forty articles excluded; therefore, eight studies investigated the role of therapeutic procedures in the assessment of APS selected.
Conclusions: Only eight studies reported novel therapeutic procedures to control refractory nausea and vomiting due to APS that we discussed in this article. Based on bibliography investigation done, the best therapeutic drugs to control refractory nausea and vomiting due to APS are: Granisetron, Aprepitant, Netupitant, Palonosetron and Olanzapine prescribing alone or in combination according to the clinical respond and under safe supervision.