A Systematic Review on Controlled Porosity Osmotic Drug Delivery System: Recent Developments and Future Prospects

Author(s): Voleti Vijaya Kumar and Ismail Y*


Objective: The current review's aim was to further explain the recent technologies adopted to develop Osmotic Drug Delivery System (ODDS).

Significance: A high quantity of In-Vitro and In-Vivo Correlation (IVIVC) is expected in ODDS.

Methods: The current review provides an overview of the fundamentals of ODDS, types, with a focus on Controlled Porosity Osmotic Pumps (CPOPs), components, suitable drug candidates, formulation strategies, coating materials, and commercially available preparations based on these systems. We have reviewed Artificial Intelligence (AI) and robotic technology, how it can be employed for designing ODDS.

Results: Osmotic systems' predicted release rate may be planned by altering the release control settings. The achievements of this medication delivery in the present and the future is indicated by the products now on the market, the patents filed thus far, and the efficacy discovered for osmotic products.

Conclusion: A promising approach for oral medicine administration is ODDS, these formulations comprising the osmotic agent, pore forming, and rate-controlling membrane can be designed using controlled porosity osmotic technology. The regulation of medication release according to the required time period can be achieved by optimizing these parameters. This method enables the release to be pulsed during a defined period of chronotherapy.

image 10.4303/JDAR/236261

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