The Effect of Thiamine Administration on Interleukin-6 (Il-6) Enzyme, Lactate and Sequential Organ Failure Assessment (SOFA) Score in Patients with Sepsis
Author(s): Akhyar Hamonangan Nasution* and Riza Stya Yulianda
Abstract
Background: Thiamine, in particular, plays an important role in the treatment of sepsis because it plays a role in Interleukin-6 (Il-6) Enzyem and Lactate.
Method: We conducted a thiamine administration on 24 sepsis patients (SOFA score ≥ 2) divided into 2 groups (thiamine and placebo groups). Thiamine was given in the size of 200 mg per intravenous drop per 12 hours for 72 hours. This study was carried out randomly from January to February 2020, and is an experimental controlled intervention study to examine the effects of thiamine on levels of Interleukin-6 and Lactic Acid, and SOFA scores in sepsis patients. The parameters measured were IL-6, lactic acid and SOFA scores.
Results: In the thiamine group, IL-6 levels were lower compared to the control group, but the difference was not statistically significant. Lactic acid and SOFA scores did not change in both groups and were not statistically significant. The mean value of serial Interleukin-6 in group A at T0 (111.1 ï??± 40.6 ng/dl), T1 (111.1 ï??± 40.6 ng/dl), T2 (128.2 ï??± 80 ng/dl), and T3 (97 ï??± 45.4 ng/dl). The mean value of serial Lactic Acid in group A at T0 (2.37 ï??± 0.23 mg/dl), T1 (1.84 ï??± 0.49 mg/dl), T2 (1.47 ï??± 0.22 mg/dl), and T3 (1.36 ï??± 0.26 mg/dl).
Conclusion: We believe that the administration of thiamine can reduce levels of Interleukin-6 (IL-6) in patients with sepsis, although this study did not find significant results.