The Effect of Thiamine Administration on Catechol-O-Methyltransferase (COMT) Enzyme Level and Amsterdam Preoperative Anxiety and Information Scale (APAIS) Value in Patients with Preoperative Anxiety

Author(s): Akhyar Hamonangan Nasution*, Aznan Lelo, Elmeida Effendy and Dadik Wahyu Wijaya


Background: Preoperative anxiety increases intraoperative and postoperative morbidity and mortality. Anxiolytic premedication drugs that exist so far have adverse side effects.

Methods: We conducted a study of thiamine administration in 20 preoperative anxiety patients (APAIS value ≥ 11) divided into 2 groups (thiamine and control groups) thiamine administered 500 mg orally per 8 hours for 72 hours. The study was conducted July 2019 until October 2019, randomized, and quasi-experimental controlled intervention study to investigate the effect of thiamine administration on COMT enzyme levels and APAIS values in patients with preoperative anxiety. The parameters measured were APAIS and COMT enzymes.

Results: In thiamine group, APAIS value decreased (p=0.001) and COMT enzyme levels increased (p=0.001) compared to the control group. There is a correlation between COMT with APAIS C (r=-0.673; p=0.016).

Conclusion: Thiamine administration improves anxiety (APAIS and COMT) in elective surgery patients with general anaesthesia.

Share this article