Studies on Chemoprotective Activity of Cinnamic Acid (CA), Hexanedioic Acid (HAD) on Azaserine Induced Pancreatic Cancer in Wistar Rats
Aimed to investigate the effect of Cinnamic Acid (CA) and Hexanedioic Acid (HDA) on preventing pancreatic cancer in male albino rats induced by azaserine. The rats were divided into 6 groups, with rats in the first group serving as a control. The rats in groups 2-6 were injected with azaserine once a week for 3 weeks. Additionally, groups 3-4 received CA at doses of 20 mg/kg and 40 mg/kg, respectively, while groups 5-6 were given HDA at doses of 20 mg/kg and 40 mg/kg, respectively, throughout the experimental period. At the end of the 3 weeks, the animals were sacrificed and their blood parameters and liver enzymes were measured. The results showed that the treated rats had normalized blood parameters, reduced liver enzymes (SGOT, SGPT and ALP) and GGT, LDH and bilirubin, reduced digestive enzymes (amylase and lipase), and increased activities of enzymatic antioxidants (SOD, CAT, GR) and decreased MDA, PCC. Moreover, TNF alpha and IL 6 were further decreased while IL 10 was enhanced in Azaserine-induced pancreatic cancer. Our findings indicate that CA and HDA administration inhibits pancreatic cancer by modulating lipid peroxidation and antioxidant status, as well as preventing azaserine-induced histopathological changes. Furthermore, Cinnamic acid and Hexanedioic acid can act as chemopreventive agents for pancreatic cancer.