Our Hypotheses about the Role of Cuproferropanoptosis in Neurocysticercosis and a Comprehensive Review

Author(s): Mercedes Nico Garcia, Lourdes de Fatima Ibanez Valdes and Foyaca-Sibat Humberto*


Background: Neurocysticercosis (NCC) is a parasitic disease secondary to a cestode infection by the larva form of pig tapeworm Taenia solium (Ts). In this study, we look for publications related to the role played by cuproptosis, ferroptosis and PANoptosis in the pathogenesis of NCC. After reviewing this issue, we formulate some hypotheses regarding their role in this zoonotic and neglected parasitic disease.

Method: We searched the medical literature comprehensively, looking for published medical subject heading (MeSH) terms like "neurocysticercosis", "pathogenesis of neurocysticercosis", "comorbidity in NCC" OR "cuproptosis" OR "necroptosis"; OR "pyroptosis"; OR "ferroptosis"; OR "apoptosis"; OR Programmed cell death"; OR "regulated cell death" and NCC.

Results: All selected manuscripts were peer-reviewed, and we did not find publications related to Cp, Fp, Py, Ap, or NCC.

Comments and concluding remarks: We have hypothesized the role of CUFEPANp on the mechanism of local NC/GC survival/growth in the perilesional cystic area. This review was the first study to comprehensively analyses the association between copper-induced CD and NCC in combination with Fp and PANp, which we named CUFEPANp. Based on this comprehensive review, we delivered several hypotheses on the participation of Cp, Fp, and PANp in NCC. However, future well-designed investigations will support or deny the hypotheses proposed in the present manuscript.

image 10.4303/JDAR/236265

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