Potential Indonesian Herbs to Develop a Mix Herbal Immunomodulator Supplement: A Hermeneutic Systematic Review
To date, only few studies summarize which herbal plants mostly studied in immunity. This study aims to search for the most Indonesian herbs studied as immunomodulators and to identify their potencies. The findings hopefully could lead to a new formula for herbal immune supplements. This systematic review was designed with a hermeneutic approach, following PRISMA guidelines. Literature searching was performed in Google Scholar and the Indonesian Scholar Database, using the Boolean operator and citation tracking. Relevant articles were identified to list the most Indonesian herbs studied as immunomodulators. Quality assessment was conducted with Newcastle-Ottawa Scale and the extracted data were analyzed descriptively. Record identification hit 574 articles, of which were screened, resulting to 241 studies. Data extraction was taken from 17 studies. Among the most herbal studied, Phyllanthus niruri, Andrographis paniculate and Nigella sativa reveal to be the potential herbal plants to develop a new herbal mix immunosupplement, due to their proinflammatory and phagocytic- activator properties.