In Vivo Schizonticidal Activity of Tribal Folklore Herbs of Western Ghats, Coimbatore, Tamil Nadu
Background: Folklore medicinal plants Solanum trilobatum, Spathodea campanulata, Syzygium jambos and Tylophora indica fractions were examined for their antiplasmodial property in rodent malaria parasite Plasmodium berghei infected Swiss albino mice model.
Method: Three in vivo assays (Peter’s four-day test, Rane’s curative and Prophylactic assay) were used in the study to determine the efficacy of plant extracts against Plasmodium berghei infection in the rodent model.
Results: Peter’s four-day test showed significant parasite suppression of 97.72% (p?0.001) in Chloroquine (CQ) control group prolonging the mean survival time of animals for 32 days. Furthermore, effective parasite control (p<0.01) of 72.72% and 63.63% has been noticed in TICLE and SJCLE respectively at 400 mg/kg b.wt, whereas the SJMLE unveiled 61.36% chemosuppression accomplishing a statistical significance of p<0.05. The leaf extracts TICLE, SJCLE and SJMLE prolonged the mean survival time of mice groups up to 24.3 ± 2.84, 21 ± 0.57 and 20.6 ± 0.8 days respectively. Among the optimistic test extracts TICLE, SJCLE and SJMLE screened from the Peter’s four day test, the TICLE exceptionally disclosed dose dependent parasite suppression of 46%, 57%, and 63% at 100 mg/kg, 200 mg/kg, and 400 mg/kg b.wt respectively in Rane’s Curative assay but not up to the level of CQ control.
Conclusion: The present investigation establishes; the selected plant species were effective in assorted range of antiplasmodial activity and could be a potential source in antimalarial drug discovery.