Design and Characterization of Dolutegravir Sodium Loaded Solid Lipid Nano Particles

Author(s): Prasanth Y*, S. Madhusudhan, Shaik Harun Rasheed and P. Veera Lakshmi


Dolutegravir loaded SLN were prepared by using hot homogenization technique followed by ultra-sonication method. A 32 full factorial design has been employed to produce. The statistical optimization reduced the number of experiments that were carried out for obtaining formulations with desired properties. The derived polynomial equations, response and contour plots helped in predicting the values of selected independent variables for preparation of optimum SLN with desired properties. Solid lipid nanoparticles showed minimum particles size, optimum zeta potential and higher %EE. This experimental design revealed that Phospholipon 90H based formulation showed better result compared to Sphingomyelin, Soya Phosphatidyl Ethanolamine based formulations which could be due to maximum carbon chain length and high phase transition temperature. The drug excipients characterization parameters reveal that there is no drug-excipients interaction.

image 10.4303/JDAR/236243

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