Combination Therapy of Vitamin C and Thiamine on Matrix Metalloproteinases-9 (Mmp-9) for Septic in ICU

Author(s): Bastian Lubis*, Ratna Akbarie Ganie, Aznan Lelo, Dadik Wahyu Wijaya, Delfitri Munir and Akhyar Hamonangan Nasution


Introduction: Sepsis is a systemic and syndromic response to infection and is a common final pathway to death from many infectious diseases. Matrix metalloproteinase 9 (MMP-9) are potential sepsis biomarkers. Ascorbic acid and thiamine administration has been suggested to affect MMP-9 in several critical conditions, such as sepsis.

Methods: This study investigated effects of combination therapy of vitamin c and thiamine on MMP-9 in sepsis patients. A true experiment with pretest posttest control group and double blind design and randomized. This study conducted at Department of Anesthesiology and Intensive Therapy, including Intensive Care on April-December 2020.

Results: Based on the initial MMP-9 values, the levels of this enzyme increased in the NaCl 0.9% group, while in combination group, MMP-9 levels decreased after the intervention (17.9%). A significant decrease in MMP-9 was found in the ascorbic acid 231,5 ? 345,5 ng/ml (p=0.026).

Conclusion: In conclusion, combination therapy of vitamin c and thiamine as a adjuvant therapy in sepsis can reduced the MMP-9.

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