Characterization and Evaluation of Trans-Dermal Patches of Acalypha indica in Nanobubbles for Rheumatoid Arthritis

Author(s): Kishore Babu*, Ragi Mercy Rani and Rajiv Rajpal kukkar


Herbal medicine is the oldest medicine that has been following from olden days to still now. It plays a major role in treating of different types of illness mostly in relieving of pain and from the conventional strategies are being used from the traditional medicine like ayurveda, unani and siddha. This is a custom therapy that has become fundamental now a days and has been the preferable one in the treating of wellspring of clinical treatment. Acalypha indica is the weed plant that has a wide range of medicinal qualities for the human well-being and it can be regularly seen in areas of India Pakistan, and Thailand. Chemical constituents are found in different parts of the plant and they are utilized for treating of different types of illness like eye contaminations, respiratory sickness, skin issues etc. Soxhlet apparatus is used for getting accurate and more reliable results. Paw induced oedema model is used to determine the analgesic activity. The 4 different types of extracts are used to determine analgesic activity by grouping the animals into 12 groups with different doses of 200 mg/kg and 400 mg/ kg are carried out in these groups Carrageenan control, AIEAF (200 mg/ kg and 400 mg/kg), AIAF (200 mg/kg and 400 mg/kg), AIEF (200 mg/kg and 400 mg/kg), AIMF (200 mg/kg and 400 mg/kg), AIWF (200 mg/kg), Diclofenac sodium (10 mg/kg) as standard reference and with different doses and compared the results to determine the analgesic effect. Results were plotted by using one-way Annova.

image 10.4303/JDAR/236235

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