Association of Sepsis-Related Mortality with Early Increase of MMP-9, TIMP-1, TIMP-1/MMP-9 Ratio

Author(s): Bastian Lubis*, Aznan Lelo, Akhyar Hamonangan Nasution, Tasrif Hamdi and Putri Amelia


Background: Sepsis causes high morbidity. Matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of matrix metalloproteinase 1 (TIMP-1) are involved in homeostasis, tissue regulation, physiological processes, angiogenesis, wound healing, and immunity.

Method: We conducted an observational and prospective study from all sepsis patients who received sepsis therapy in the Emergency Department and Intensive Care Unit were recruited between April to September 2020 at the Haji Adam Malik General Hospital and Hospital Networks. We measured circulating levels of TIMP-1, MMP- 9, TIMP-1/MMP-9 ratio, NLR and SOFA score as estimated mortality in critically ill patients.

Results: We found higher MMP-9, TIMP-1, and TIMP-1/MMP-9 ratio during 24 hours (n = 72). The levels of TIMP-1, MMP-9 differed significantly with the difference of sofa score or mortality rate in septic patients (p=0.001).

Conclusion: Septic patients showed persistently higher TIMP-1/ MMP-9 ratio during 24 hours, which was associated with severity, and mortality, thus representing a new biomarker of sepsis outcome

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