Anti-Inflammatory Activity of a Mixture of Peppermint and Thyme Volatile Oils

Author(s): Bubueanu Corina*, Rasit Iuksel, Paraschiv Ileana, Moga Sorin, Ducu Catalin, Panteli Minerva and Pirvu Lucia


Volatile oils of Mentha piperita and Thymus vulgaris are often components of products used for anti-inflammatory properties. This work shows the chemical composition of a mixture of those two volatile oils and the anti-inflammatory activity in topical administration. Eleven compounds were identified by GC analysis and marker compounds menthol and men- thone for peppermint volatile oil and thymol and carvacrol for thyme vol- atile oil were also identified by HPTLC. The anti-inflammatory activity of a 2% mixture of volatile oils of Mentha piperita and Thymus vulgaris incarrageenan-induced mouse paw edema model, in comparison with Vol- taren (23,2 mg/g diclofenac diethylamine) was slightly weaker compared with the group treated with Voltaren, but differed significantly from the control, at all measurement times

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