B. Mallikarjuna
Department of Chemistry, Government College, IndiaPublications
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Research Article
Stability-Indicating HPLC Method for Simultaneous Determination of Drugs Nivolumab And Ipilimumab
Author(s): Sharmila Alladi*, Konda Ravi Kumar and B. Mallikarjuna
A simple, accurate, specific and rugged reverse phase liquid chromatographic method was developed for the simultaneous estimation of Nivolumab and Ipilimumab in bulk and tablet dosage form. A RP Inertsil ODS, having dimensions of 150 × 4.6 mm and particle size of 3.5 μ in isocratic mode, with mobile phase containing a mixture of 0.1% orthophosphoric acid and acetonitrile in the proportion (50:50 v/v). The mobile phase was pumped at a flow rate of 1.0 ml/min and the eluent were monitored at 225 nm... Read More»
DOI: 10.4303/jdar/236194