The Influence of Pharmacological Osteoporosis Treatment on Refractures Following a Kyphoplasty

Author(s): Imran Alam*


The aim of this study was to examine the relationship between pharmacological osteoporosis treatments on the refracture rate in patients who have had a thoracic or lumbar level Kyphoplasty. A Kyphoplasty is a non-invasive vertebral augmentation surgery used to treat compression fractures. A single center observational cohort study with 192 patients who had Kyphoplasty from 2015 until 2019 was conducted. The cohort was divided into two main groups with a 1:1 ratio. A Chi Square Independence Test, a 2 tailed 2 sample difference of proportions Z-test, and a confidence interval were used to analyze the data. The Chi Square Independence Test suggested a strong dependent relationship between pharmacological osteoporosis treatment and the refracture rate following kyphoplasty and determined significance in data. In addition, by taking pharmacological treatment, the patient has 13.54 percentage points to reduce the refracture rate to 0 compared to when patients were not taking medication. This study gave physicians a treatment method to reduce the chance of patients having recurrent fractures due to a Kyphoplasty. Thus leading to far less future kyphoplasty procedures. Keywords: Bone transport; Chronic osteomyelitis; External fixator; Femoral defect

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