Author(s): Gisele Carla de Palma and Fabio Navarro Cyrillo
Abstract
Abstract
The effects of varenicline, a good drug for smoking stop, on chamber and chamber electrical phenomenon stay unknown. To judge the consequences of varenicline on rate, PR interval, QT interval and QT dispersion (QTd). A complete of sixty smokers was prospectively listed within the gift study. Twelve-lead ECG recordings were obtained for all subjects before and on the fifteenth day of drug administration. Electrocardiograms were recorded at amplitude of 20 mm/mV and a sweep speed of 50 mm/s. The mean (± SD) age of the volunteers was 38±10 years. 34(57%) were male. 14 (23%) had high blood pressure, 8 (13%) had polygenic disorder and 6 (10%) had chronic hindering respiratory organ disease. The mean rate was 74.7±13.3 beats/min, and mean heartbeat and beat blood pressures on admission were 122.3±14.3 mmHg and seventy six.5±10.2 mmHg, severally. Rate and heartbeat and beat blood pressures failed to modification with varenicline treatment. Varenicline treatment resulted in restricted prolongation in PR interval, that approached significance (163.5±18.3 ms versus 168.2±17.9 ms; P=0.053), whereas RR interval (796.3±117.4 ms versus 798.3±123.7 ms; P=0.926), QT interval (384.1±17.5 ms versus 383.4±20.9 ms; P=0.852) and QTd (52.6±14.9 ms versus 52.2±14.9 ms; P=0.919) weren't considerably modified. Varenicline had a restricted result on chamber conductivity, whereas it had no result on rate, QT interval and QTd. more studies are required to prove the consequences of varenicline on the conductivity system of the center, particularly on PR interval.