Commentary Article - Journal of Evolutionary Medicine ( 2021) Volume 9, Issue 6

A Description on Human Genetic Variation

Tony L Goldberg*
Department of medicine, University of Wisconsin-Madison, USA
*Corresponding Author:
Tony L Goldberg, Department of medicine, University of Wisconsin-Madison, USA, Email:

Received: 06-Dec-2021;Accepted Date: Dec 20, 2021; Published: 27-Dec-2021


The distinction in DNA between individuals or between populations is referred to as genetic differences. Mutation and hereditary replication are two of the many sources of genetic differences. Although mutants are the primary source of genetic variation, other processes such as sex- ual reproduction and genetic drift also contribute to it. There are numerous levels of genetic differences that can be recognized. Findings of morphological characters in ei- ther quantitative characters (traits that vary constantly and are programmed for by much genetic makeup (e.g., leg length in dogs)) or discrete traits (traits that fall into dif- ferent classes and are programmed for by one as well as a few genes) can be used to identify the genetic variability. The process of protein electrophoresis could also be used to identify genetic variation at the level of enzymes. Poly- morphic genes contain multiple alleles at each locus. Poly- morphisms may occur in half of the genes responsible for enzymatic in insects and plants, whereas polymorphisms become less prevalent in vertebrates. Finally, gene mutation is caused by the differences in the sequence of bases in nu- cleotides in genes. Researchers can now straight sequence DNA, revealing even more genetic differences than it was previously discovered by protein electrophoresis. DNA analysis revealed genetic differences including both cod- ing and noncoding intron regions of genes. If distinctions in the sequence of nucleotides in the DNA sequence result in differences inside the sequence of amino acids in pro- teins coded by such a DNA sequence, so if the subsequent distinctions in amino-acid sequence influence the form, so the function, of the enzyme, genetic variation will result in morphological characters, There are no 2 humans who are genetically similar. Even monozygotic twins (who develop from same zygote) have infrequent genetic differences due to developmental mutants and dna copy variability. Person- al characteristics, even between related species, are now at the heart of methods such as dna profiling. There are 324 million recognized variations from sequential genomic se- quences as of 2017. The average distinction between being an individual’s genome as well as the reference genome has been approximated to be 20 million base pairs in 2015. (or 0.6 percent of the total of 3.2 billion base pairs). Alleles occur at varying rates for different populations. Population numbers that really are geographically and ancestrally dis- tant from one another appear to vary more. Difference in population account for a small proportion of total genetic variation. Populations vary in the level of variation among their members as well. The greatest population deviation is found in Sub-Saharan Africa, which is consistent with non-African populations’ recent African origin. Populations differ in the proportion as well as location of introgressed genetic makeup received through archaic admixture both within and without Africa, Human genetic variability re- search has evolutionary implications as well as medical ap- plications. It can aid researchers in understanding ancient human population migrations and also how human groups are genetically compatible to one another. The research of genetic variation may be important in the medical field since some illness alleles are more common in people from specific geographic locations. According to new research, each person has an estimated 65 new mutations when tried to compare to their parents.